Putting the brakes on age-related idiopathic pulmonary fibrosis: can Nox4 inhibitors suppress IPF?

Section Editor: Werner Zwerschke myofibroblasts, which then overproduce extracellular matrix (ECM) proteins (Camelo et al., 2014). Histologically, IPF presents with patches of fibroblastic foci with temporal heterogeneity (King et al., 2001). These foci are comprised of myofibroblasts, which damage the alveolar epithelium through continuous fibroblastic proliferation and ECM production (Camelo et al., 2014; King et al., 2001). Between these islands of myofibroblasts are areas of dense fibrosis and chronic inflammation (Katzenstein and Myers, 1998). A recent study by Hecker et al. compared the development of lung